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https://ars.els-cdn.com/content/image/1-s2.0-S0021979721013588-ga1.jpg MOTC Glutamate-Glutamine cycle | Astrocyte in glutamate-glutamine metabolism Color:Teal Together, our observations that a small molecule NNMT inhibitor can increase NAD + and SAM concentrations in differentiated adipocytes and reduce adiposity in DIO mice, suggest that treatment with an NNMT inhibitor effectively reverses obesity via modulation of the NAD + salvage and SAM-mediated (e.g., polyamine flux) pathways to regulate energy expenditure in the adipose tissue
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