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https://journals.sagepub.com/cms/10.1089/ars.2020.8129/asset/6dbcd327-bee4-4534-b831-ad34e2fafc4c/assets/graphic/10.1089_ars.2020.8129-fig2.jpg skin whitening lotion B12 injection Cor:Bege Médio 10,11 This compositional change affects host metabolism via the gut–liver axis: conjugated bile acids act as antagonists of FXR in the intestine, inhibiting the intestinal FXR-FGF15/19 signaling pathway, leading to upregulation of hepatic cholesterol 7α-hydroxylase expression and accelerating the conversion of cholesterol to bile acids, but may also promote hepatic lipogenesis

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