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10,11 This compositional change affects host metabolism via the gut–liver axis: conjugated bile acids act as antagonists of FXR in the intestine, inhibiting the intestinal FXR-FGF15/19 signaling pathway, leading to upregulation of hepatic cholesterol 7α-hydroxylase expression and accelerating the conversion of cholesterol to bile acids, but may also promote hepatic lipogenesis
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Specific probiotic strains can act as a “buffer,” helping your gut microbiome adapt to these rapid metabolic changes
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