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The peptide problem: Hype is outrunning the evidence

Unlike the results found in previous studies, the effect of high dose N -acetylcysteine on air trapping and airway resistance of chronic obstructive pulmonary disease, a double-blinded, randomized, placebo-controlled trial (HIACE) conducted with 120 patients with stable COPD (58 treated with 600 mg of oral NAC twice a day and 62 with placebo), demonstrated a significant improvement in the function of the small airways, in addition to a reduction in the frequency of exacerbation of the disease [53]

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In addition to functional similarities, there is sequence homology between AngIV, its analogs, and a small, six-amino-acid domain of HGF termed the “hinge” region, which participates in the process of HGF dimerization (Kawas et al., 2012)