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Interestingly, the 1.8 kb 5′-flanking region of the rat GCLC does not contain any consensus ARE element (5′-G/ATG/TAG/CNNNGCA/G-3′) (Erickson et al., 2002), but the reporter activity driven by a recombinant rat GCLC-luciferase construct is induced by TBH (Yang et al., 2005a)
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