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[DOI] [PubMed] [Google Scholar] 119.Yu C., Cao J., Wang L., Yang Y., Ni Y., Wang J

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This reprogramming accelerates glutamine metabolism, producing large amounts of ammonia as a byproduct, which accumulates intracellularly and triggers cell death ( Inhibiting pathways associated with ammonia-induced cell death can enhance CD8+ T-cell survival, significantly improving the effectiveness of adoptive cell therapy ( Current targeting strategies continue to confront a triple paradox: First, while inhibition of glutamine metabolism enhances memory differentiation of T cells (60), it may exacerbate nutrient competition within the tumor microenvironment