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In addition, knockout of hepatic CYP 450 reductase could exacerbate triptolide -induced toxicity in mice (Xue et al., 2011), while pretreatment with CYP3A inducer of dexamethasone could protect against triptolide originated liver injury in rat (Ye et al., 2010), suggested CYP 450s mediated the metabolic activation of triptolide, leading to hepatotoxicity
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