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2).20 The function of occludin is not yet fully understood, but numerous studies using animals and cell cultures indicate that it has crucial roles in the TJ structure and permeability in the intestinal epithelia.21 Recent studies showed that knockdown of occludin induces an increase in paracellular permeability to macromolecules, which indicates that occludin plays a role in the maintenance and assembly of TJs.21 In the intact epithelium, occludin is highly phosphorylated on the serine and threonine residues,22 and the phosphorylation has a role in the maintenance and assembly of the TJ structure.23 Some kinases, such as protein kinase C (PKC) and casein kinase, have been identified as responsible for its phosphorylation.24,25 In addition, although the level of tyrosine-phosphorylated occludin is very low in the intact epithelium, several studies have shown that tyrosine phosphorylation is caused during disassembly by various stimuli.26 Underlying this mechanism, the tyrosine phosphorylation of occludin attenuates the interaction with ZO-1, leading to dissociation from the junctional complex

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We typically prescribe CJC-1295/Ipamorelin in patients over 35 with diffuse thinning, age-related hair changes, or patients who are also seeking the broader anti-aging and body composition effects of the GH axis