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FIGURE 8 Additional stability and degradation escape of CD44v9-xCT complex is carried out through interaction with ubiquitin thioesterase/otubain-1 (OTUB1), a deubiquitinating enzyme (DUB) that plays a vital role in regulating protein stability by removing ubiquitin molecules from target proteins, thereby preventing their degradation by the proteasome and as a result mediating ferroptosis (Liu et al., 2019

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On the other hand, activation of NF- κ B in neurons promotes cell survival and can protect neurons in experimental models of acute and chronic neurodegeneration (Camandola and Mattson, 2007)