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Historical and contemporary trials have evaluated intramuscular, intravenous, and local subcutaneous administration of MeCbl in conditions such as amyotrophic lateral sclerosis, peripheral neuropathy, neuropathic pain, and autism spectrum disorder.2,6 These uses are reported as investigational, and the available studies are generally limited by small sample sizes, relatively short treatment durations, and, in several cases, open-label or otherwise nonblinded designs