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5-Amino-1-methylquinolinium iodide is the lead first-in-class small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT) — an enzyme overexpressed in white adipose tissue of obese individuals where it consumes the methyl-donor pool and depletes tissue NAD⁺

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A deficiency of vitamin B12, therefore, results in reduced production and maturation of cells with high turnover particularly red blood cells