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Even in the animals, the picture is not that simple: the mouse effect on fat depended on frequent dosing (three times daily in the pivotal study) and a specific obese-on-high-fat-diet context, and whether the effect would persist, plateau, or rebound after stopping was not the question those short studies were built to answer

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Many participants expressed a desire for clinician-guided treatment but felt they had no choice due to dissatisfaction with their current care and a need to improve their quality of life