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Consider dose adjustment if: Insomnia persists beyond 12 to 16 weeks at a stable dose Sleep disruption is severe (less than 5 hours of sleep per night consistently) Insomnia is affecting work performance, mood, or safety (driving while sleep-deprived) You've tried the full sleep restoration protocol with no improvement You have other intolerable side effects in addition to insomnia Dose reduction (for example, from 2.4 mg to 1.7 mg semaglutide) often improves sleep while maintaining most of the weight-loss benefit

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Smaller peptides (under 1,000 Da) tend to be more stable and easier to reconstitute, while larger peptides may require specific solvents or lower temperatures to maintain structural integrity