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The KEAP1 gene, located on 19p13.2, encodes Keap1 (Kelch-like ECH-associated protein 1) and is a cytoplasmic protein that negatively modulates Nrf2 through its five domains (three BTB, one IVR, and two DGR domains), promoting Nrf2 ubiquitination and subsequent proteasomal degradation via the Cul3-Roc1 E3 ligase complex under basal conditions [83,84]

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At neutral pH, these residues lose their charge, molecules attract each other, and you get aggregation