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3.1.2 Mechanisms of cuproptosis regulation in KOA In chondrocyte injury, dysregulated copper homeostasis leads to intracellular copper accumulation, which triggers cuproptosis via dual mechanisms: (i) direct binding to lipoylated TCA cycle enzymes (e.g., DLAT, PDHA1), inducing protein aggregation, mitochondrial respiratory dysfunction, and energy metabolism collapse
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