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xanthine oxidase inhibitor prevents production of uric acid useful in both patients with increased synthesis and decreased clearance of uric acid can be used in mild-moderate renal impairment rarely associated with bone marrow suppression and hepatotoxicity Pegloticase Uricase is an enzyme that converts poorly soluable urate (uric acid) to the more soluable allantoin (excreted in the urine)

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Immunofluorescent staining in iPSC-derived brain organoids Day 50 and day 100 of cBOs of different conditions embedded in OCT were sectioned at 10 µm using the cryotome (Microm HM525, Thermo Fisher Scientific)