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It has been demonstrated that acetylenic oxylipins are able to inhibit NF-κB and the formation of proinflammatory cytokines and inflammatory enzymes such as interleukins (ILs), cyclooxygenases (COXs), and lipoxygenases (LOXs), suggesting that the direct inhibition of these inflammatory mediators may be the mechanism of action adopted by these compounds for the prevention and treatment of cancer (Figure 6)