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Thyroid hormones, particularly triiodothyronine (T3) and thyroxine (T4), are transported across the bloodβbrain barrier (BBB) by specialized carriers and are metabolically activated or inactivated by local deiodinase enzymes ( Current therapeutic paradigms focus primarily on pharmacological hormone replacement, most commonly levothyroxine ( In response, attention has turned to complementary strategies that address the multifactorial nature of thyroidβbrain dysfunction
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