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The proposed mechanisms of AOD-9604 include: Stimulating lipolysis: Promoting the breakdown of stored triglycerides in adipose (fat) tissue Inhibiting lipogenesis: Reducing the formation of new fat from circulating fatty acids and glucose Mimicking the lipolytic domain of hGH: Interacting with the beta-3 adrenergic receptor pathway, which plays a role in fat metabolism No effect on IGF-1: Unlike full hGH, AOD-9604 does not raise insulin-like growth factor 1 levels, theoretically avoiding the growth-promoting (and potentially cancer-promoting) effects of hGH No effect on blood sugar: It should not cause the insulin resistance associated with full hGH These mechanisms were demonstrated primarily in in vitro (cell culture) and animal studies , particularly in obese mice and rats
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It is not a clinical outcome, and the leap from “modulates gene expression in vitro” to “produces a therapeutic effect in a person” is exactly the leap that most preclinical findings fail to make
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