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[DOI] [PMC free article] [PubMed] [Google Scholar] 15.Huang J., Weinstein S.J., Yu K., Männistö S., Albanes D
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Since the 5 α -reductase-1 activity is 3 to 4 times greater in malignant than in benign prostate tissues, while the 5 α -reductase-2 activity is similar in these 2 diseases 91 , whether inhibition of both isozymes by combination of specific type 1 and type 2 inhibitor or using dual inhibitor is more effective in the prevention and therapy of prostate cancer is an interesting strategy and remains to be determined
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