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Cell Stem Cell 31 , 1145–1161.e1115 (2024)

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Moreover, the finding that Cyp2e1 −/− mice were resistant to the hepatotoxicity caused by high doses of APAP, while the same knockout mice transgenically expressing human CYP2E1 were susceptible (84) indicates that CYP2E1 is indeed the main P450 enzyme involved in APAP activation