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7 These pretreatment doses and times were selected based on other previous studies 1 , 7 and preliminary experiments in which the safety after injection was determined, since we used rats as the experimental animals

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In β3-AR knockout mice, however, no effect was observed with AOD9604 — confirming the dependency of its chronic lipolytic action on β3-AR expression, while also suggesting an additional acute mechanism that may operate through a separate pathway