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discussed HR function restoration, DNA replication fork stabilization, BRCA reversion mutations, dissociation of PARP1 and PARG, and epigenetic modifications as some of the well-studied mechanisms of PARP inhibitor resistance [193]
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Collagen synthesis capacity decreases by 1-2% annually after age 25, potentially requiring extended treatment cycles of 12-16 weeks versus 8-10 weeks in younger subjects
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