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When zonulin signalling is dysregulated — triggered by bacterial colonisation, gluten exposure, or chronic stress — tight junctions open, and the gut barrier loses its integrity.4 Elevated zonulin has been directly linked to insulin resistance, type 2 diabetes, and cardiovascular risk in human studies.5 What BPC-157 Does to the Intestinal Barrier BPC-157 targets the intestinal barrier through several parallel mechanisms: Tight junction restoration
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