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Frontiers | Redox metabolism in cell senescence: focusing on contributions from the metabolomic field
In the case of SUR, the cause may be dysregulation of glutamatergic neurotransmission: Phelan-McDermid Syndrome produces disruption in the SHANK3 gene, which encodes a scaffolding protein in glutamatergic synapses, and produces a specific autistic phenotype in which SUR is considerably more prevalent than in idiopathic autism (Tavassoli et al., 2021)
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We found LEF-1 expression to be positively correlated to CTNNB1 staining and an easy to assess marker of the Wnt/β-catenin pathway activation
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