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Glutamatergic neurons are neurons that make and release glutamate, but other types of neurons, such as dopaminergic and cholinergic neurons, can also have glutamate receptors.[ref] There are two main types of glutamate receptors:[ref] Ionotropic receptors: AMPA, NMDA , and kainate receptors, which are fast, excitatory receptors Metabotropic receptors: G-protein coupled receptors that modulate the release of glutamate and other neurotransmitters, as well as being involved in synaptic plasticity Binding to the various glutamate receptors then causes a variety of actions in the neuron
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Consequently, their expansion contributes to gut dysbiosis through mechanisms such as competitive overgrowth, epithelial barrier disruption, and promotion of inflammatory responses, often in synergy with other opportunistic microbes
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