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Similarly, a random forest model constructed with the optimal parameter mtry = 3 identified the top five genes as AHR , SLC1A5 , HSD3B7 , PPARG , and CD36 ( Figure 2C )

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granulosus TGR lacking the Grx domain [61] and mammalian TGR with Sec614Ser mutation or truncated TGR Cys613Stop [10] lack any residual GR activity suggesting that GSSG reduction occurs exclusively by the Grx domain in these orthologs