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Box B: Heterotrimeric versus monomeric G proteins Heterotrimeric G proteins Have three subunits: αβγ Activated by GPCRs Active when GTP is bound to α Turned off when α cleaves GTP to GDP The α subunit has much homology with the monomeric G proteins Monomeric G proteins Have only one subunit Low molecular weight Active when GTP is bound Turned off when they cleave GTP to GDP Signaling by Ras will be discussed in the section on signaling by receptor tyrosine kinases