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αKG drives histone acetylation Carnitine is needed to transport short and long acyl groups across the inner mitochondrial membrane, and acylcarnitines are known to be important for both energy production and redox balance 22,23

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Specifically, TLR4 signaling has been implicated in microglial activation and neuroinflammation in glaucomatous retinas, while the NLRP3 inflammasome plays a role in caspase-1-mediated pathways that can further exacerbate neuronal injury (154–156)