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ECG Recording ECGs were recorded continuously in deeply anesthetized rats for all three main leads, by positioning stainless-steel electrodes on all four limbs using an ECG monitor with a 2090 programmer (Medtronic, Minneapolis, MN, USA) connected to a Waverunner LT342 digital oscilloscope (LeCroy, Chestnut Ridge, NY, USA) (before the procedure, after haloperidol, fluphenazine, clozapine, risperidone, olanzapine, quetiapine, or aripiprazole, domperidone, amphetamine, and combined amphetamine and haloperidol, after therapy application, and before sacrifice)
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Although SIRT1 is mainly a nuclear protein, SIRT1 deacetylation of peroxisome proliferator-activated receptor PGC-1 α has been widely involved in metabolic control and mitochondrial biogenesis, which was considered as part of the basis of SIRT1 in energy limitation
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