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For lipid peroxyl radical scavenging, FSP1 inhibitors have been widely pivotal: first-generation iFSP1 is human-specific, limiting preclinical use, whereas next-generation, species-independent inhibitors like viFSP1 effectively target FSP1’s NAD(P)H-binding pocket and show therapeutic promise when combined with sorafenib via biomimetic nanoparticles [124]
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