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Strong correlations were also evident for dissociative disorders ( r g = 0.63, P = 5.0 × 10 −6 ), somatoform disorder ( r g = 0.67, P = 8.8 × 10 −26 ) and depression ( r g = 0.63, P = 4.1 × 10 −118 ), alongside more modest correlations with generalized anxiety disorder ( r g = 0.46, P = 3.8 × 10 −20 ) and insomnia ( r g = 0.47, P = 2.0 × 10 −43 )

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While SOX2 gene expression decreased at the initial stages of differentiation, we observed a developmental lag in the decrease of downstream modalities including SOX2 ADT levels and SOX2 transcription factor activity as estimated by chromVAR (Fig