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The risk of patients suffering harm from their medicines increases with polypharmacy, and treatment regimens (including non-pharmacological treatments) can very easily become burdensome for patients with multimorbidity and can lead to care becoming fragmented and uncoordinated
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Interestingly, the combined therapy of PYY3-36 and GLP-1 receptor agonist (exendin-4) was found to decrease food intake and body weight in an additive manner in animal models and humans
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