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Mechanisms of Disease: metabolic effects of growth hormone and insulin-like growth factor 1 | Nature Reviews Endocrinology
By selectively blocking NNMT, 5-Amino-1MQ is investigated for its ability to preserve cellular NAD+ pools, reduce methylation of nicotinamide to inactive 1-methylnicotinamide (1-MNA), and enhance sirtuin activity and energy metabolism
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However, BPC 157 is relatively stable and small dose ranged between ng-μg/ml or ng-μg/kg is already effective on promoting tissue injury healing and angiogenesis in many animal studies 4,27–30
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