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Transport Mechanisms Involved in Plasma Membrane GSH Efflux During Cell Death GSH is a ubiquitous tripeptide produced intracellularly that is not only 85%–90% freely distributed in the cytosol, but can also be found compartmentalized in mitochondria, peroxisomes, nuclear matrix, and endoplasmic reticulum (ER) (Table 1 and Fig

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There is a cross-tolerance between alcohol, benzodiazepines, barbiturates, nonbenzodiazepine drugs, and corticosteroids, which all act by enhancing the GABAA receptor’s function via modulating the chloride ion channel function of the GABA A receptor [233,234,235,236]