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Mitochondria-derived ROS contribute to immunogenic cell death signaling by promoting danger-associated molecular pattern (DAMP) release and immune recognition

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However, in a much larger randomized controlled trial of simvastatin and an antioxidant combination of 600 mg of all - rac -α-tocopherol (297 mg of RRR -α-tocopherol), 250 mg of vitamin C, and 20 mg of β-carotene daily) in more than 20,000 men and women with CHD or diabetes mellitus, the antioxidant combination did not adversely affect the cardioprotective effects of simvastatin therapy over a five-year period (131)