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The investigators used antisense oligonucleotides (ASO) to knock down NNMT expression specifically in white adipose tissue and liver of diet-induced obese C57BL/6 mice (n = 8 per group for primary analyses) over 8 weeks
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After serum limitation-induction, positive FOXO4 and p53-pS15 immunofluorescence staining was stronger in the nucleus of keloid fibroblasts at 48 h, but in the nucleus of normal skin fibroblasts at 72 h
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