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Consequently, the elevated levels of free radicals can damage cellular structures, resulting in the accumulation of cytotoxic substances and ultimately leading to the death of substantia nigra cells, thereby triggering the onset of PD ( 2.3.3 Neurological inflammation loop Neuroinflammation is a significant indicator of PD and plays a pivotal role in its pathogenesis and progression (Kubota et al., 2020)

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Study timeline: The study began in June 2015 and is currently recruiting, aiming to enroll about 200 participants, with an estimated completion date in June 2030