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For females, we performed both European-only and multi-ancestry meta-analyses, but for males, we performed only the European-only meta-analysis owing to the lack of male summary statistics in Genes & Health and the low number of male cases in non-European ancestries in the multi-ancestry cohorts

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ScGrx7 is particularly suited for unbiased kinetic and mechanistic studies because of its high activity, the absence of iron–sulfur clusters in enzyme preparations and the lack of additional cysteine residues 11 (glutaredoxins with two or more cysteine residues have complex kinetics because of alternative redox states and reactions 10,12,14,17,30,31,32,33 )