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While ROS production typically scales with 5-ALA concentration until enzymatic saturation, therapeutic outcomes are strictly constrained by three factors: (1) incubation kinetics, balancing cellular uptake against metabolic PpIX efflux ( Primary PpIX-photoinduced ROS leads to immediate oxidative damage to critical mitochondrial components, including CL in the IMM and the proteins of the OXPHOS complexes ( Figure 4A )

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Đây chính là lý do nhiều người lựa chọn bổ sung glutathione từ nguồn bên ngoài thông qua viên uống