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The study found that NNMT inhibitors "reduced intracellular 1-MNA, increased intracellular NAD+ and S-(5′-adenosyl)-L-methionine (SAM), and suppressed lipogenesis." This metabolic improvement occurs within days of starting treatment, before any weight loss becomes measurable

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Minas T et al (2014) found that ACI provided durable outcomes with improved function in 75% of patients with symptomatic cartilage defects at a minimum in 10 years post-surgery.35 ACI is a highly effective surgical treatment for chondropathy such as chondromalacia patella, particularly in young, active patients with large cartilage lesions