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The dual-targeted design was rationally based on GSH recognition by Na-dependent glutathione transporters enriched on brain endothelium and Glu/AMPA-receptor-mediated uptake in glioblastoma cells
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[2] [3] [4] In addition to its efficacy in epilepsy and migraine prophylaxis, topiramate has also demonstrated neuroprotective effects against hypoxic-ischemic brain damage in both in vitro and animal models
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